Is two sets really enough?

[Wik]

Is two sets of isolation exercise in the template really enough for hypertrophy? Lateral raises are only done ones a week (2 sets/week), which seems quite a lot lower than minimal effective dose suggested by Mike Israetel.

[Jordan Feigenbaum]

Presumably yes, given the RIR being used in the context of additional shoulder girdle training. That said, not everyone will respond well to this level of training and may require different and/or more training.

Finally, absolute MEV and MRV numbers are wholly made up and should not be used as guidelines for general recommendations. Rather, each individual might have different needs that should be reflected in their programming.

[Wik]

How would one modify the program for our individual needs?

[Jordan Feigenbaum]

How would one modify the program for our individual needs?

By adjusting the variables to suit the individual

For example, if an individual isn't responding well to the training from a strength perspective, e.g. their work sets, e1RM, etc. aren't trending up over the last few weeks, then we'd look at the volume, average intensity, and overall specificity compared to how much fatigue we think the individual is experiencing.

It's personal preference as far as what variable(s) you want to change, but the goal(s) tend to direct which ones you think are more likely to make a difference.