# Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?

**URL:** https://forum.barbellmedicine.com/t/branched-chain-amino-acids-and-muscle-protein-synthesis-in-humans-myth-or-reality/6797
**Category:** Nutrition Q&A \[Moderated\]
**Created:** [August 18, 2019, 8:05pm UTC](https://forum.barbellmedicine.com/t/branched-chain-amino-acids-and-muscle-protein-synthesis-in-humans-myth-or-reality/6797 "2019-08-18T20:05:31Z")
**Posts on this page:** 3
**Page:** 1

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### Author: ![bjplawrence](https://sea1.discourse-cdn.com/flex001/user_avatar/forum.barbellmedicine.com/bjplawrence/32/1328_2.png) [@bjplawrence](https://forum.barbellmedicine.com/u/bjplawrence)
#### Post date: [August 18, 2019, 8:05pm UTC](https://forum.barbellmedicine.com/t/branched-chain-amino-acids-and-muscle-protein-synthesis-in-humans-myth-or-reality/6797/1 "2019-08-18T20:05:31Z")

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Hi BBM,

Am no medical expert; but came across the above captioned article on BCAA’s. Link - ([//jissn.biomedcentral.com/articles/10.1186/s12970-017-0184-9](https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0184-9)).  
Based on the claims in this article, is it fair to assume that BCAA’s by itself, can impact MPS negatively.?

Thanks in advance.  
Bishan

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### Author: ![Jordan\_Feigenbaum](https://sea1.discourse-cdn.com/flex001/user_avatar/forum.barbellmedicine.com/jordan_feigenbaum/32/1315_2.png) [@Jordan\_Feigenbaum](https://forum.barbellmedicine.com/u/Jordan_Feigenbaum)
#### Post date: [August 19, 2019, 8:25am UTC](https://forum.barbellmedicine.com/t/branched-chain-amino-acids-and-muscle-protein-synthesis-in-humans-myth-or-reality/6797/2 "2019-08-19T08:25:47Z")

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> [@bjplawrence](#):
>
> Hi BBM,
> 
> Am no medical expert; but came across the above captioned article on BCAA’s. Link - ([//jissn.biomedcentral.com/articles/10.1186/s12970-017-0184-9](https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0184-9)).  
> Based on the claims in this article, is it fair to assume that BCAA’s by itself, can impact MPS negatively.?
> 
> Thanks in advance.  
> Bishan

No, not at all. The editorial (not a study) tries to infer that may be the case, but does have evidence to support that claim. In contrast, there are a number of papers showing BCAAs in isolation can drive MPS. Nevertheless, I do not think BCAAs are useful to supplement in isolation when someone is eating enough protein.

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### Author: ![bjplawrence](https://sea1.discourse-cdn.com/flex001/user_avatar/forum.barbellmedicine.com/bjplawrence/32/1328_2.png) [@bjplawrence](https://forum.barbellmedicine.com/u/bjplawrence)
#### Post date: [August 19, 2019, 11:23am UTC](https://forum.barbellmedicine.com/t/branched-chain-amino-acids-and-muscle-protein-synthesis-in-humans-myth-or-reality/6797/3 "2019-08-19T11:23:01Z")

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Many thanks for your clarification.