Given that risk seems to be attributed to ApoB but most of the research is on LDL-C, is it important to try reduce LDL-C if ApoB is already WNR?
I’ve recently seen someones LDL-C at 170mg/dl but ApoB at 90 mg/dl (0.9g/L). Is this still a risk factor for CVD that needs to be looked into? Is that also common to see LDL-C so high while ApoB is the “normal” range?
This is a very unusual degree of discordance between these measurements. While, in general, risk tends to track more closely with ApoB than it does with LDL-c when taken in isolation, I’m not comfortable dismissing this situation entirely, nor treating aggressively, just based on this data point alone. I would be scrutinizing the testing (and patient’s background history) more closely, and likely repeating testing at a separate time, potentially via a different lab.