Hi,
Is there any known mechanisms by which substituting non-saturated fat for saturated reduces the risk of heart disease? Wouldn’t the non-saturated fat sill have to be transported through the body via lipoproteins?
Thanks
Hi,
Is there any known mechanisms by which substituting non-saturated fat for saturated reduces the risk of heart disease? Wouldn’t the non-saturated fat sill have to be transported through the body via lipoproteins?
Thanks
There are a variety of mechanisms at play, but one major factor is modulating activity of the LDL receptor. Saturated fats suppress LDL-R function, thereby limiting the ability to clear these particles from the blood.
Regardless of the mechanisms at play, we have a massive body of consistent research evidence from tightly controlled feeding trials demonstrating the effects we describe. These are cited in the articles I wrote for the website.
Major THANKS! for those articles - my PCP recently suggested the use of statins for their protective effect in my age group (my cholesterol’s high normal) - I declined until I read your article and then immediately asked that he please write the script after all. that was the best and most understandable explanation I’ve ever come across and was instrumental in massive changes in my diet. I see wildly differing speculation as to the effect of dietary cholesterol on serum levels, but I’m sticking with the changes if only for the slightest improvement. dumped red meat, massively reduced saturated fat, moved to egg beaters (still have a couple eggs/wk. for their nutrients, and otherwise, eat only salmon, poultry, and plants. thanks for the nudge (more of a body block in terms of “turning on the light”) - will miss my habit burgers and fries, but what a small price to pay for extra years with the grandkids. anticipate this being one of the best life changes I will ever make. THANK YOU!
Thanks for the reply. I don’t know if there are studies available, but would you think MCT oil would have the same effect as other saturated fats?
The mechanisms have not been fleshed out, but foods high in MCT, which are saturated fats, tend to drive up markers that correlate with increased risk of heart disease.