lp(a) and PSA/BPH in young healthy male

Hello Doctors,

I am posting with hesitation as I know most medical matters are intrinsically beyond the scope of what can be accomplished in this forum, however I value your expertise and knowledge to such a high degree that I’m impelled to ask your opinion(s).

I am a 37 year old male, and recently underwent bloodwork, urinalysis, and ultrasound due to exhibiting symptoms of prostatitis.
Thankfully my results came back negative, however I have a few areas of concern.

  1. I was told that the ultrasound confirmed my prostate is slightly enlarged, but not of concern, and that I should be okay to manage symptoms (urinary hesitancy) via lifestyle (don’t drink before bed) and medication could be pursued if needed.
  2. My PSA reading came back as 1.6 ug/l, which I understand is above average for my age but under the threshold to indicate any clinical significance or need to address, so again this was something I was told could be monitored but is a non-issue.
  3. My doctor had a lp(a) reading done due to family history of ASCVD, and my result was 218 nmol/L, which I also understand is quite high but in my doctor’s words “I’ve seen 400, so it’s not that bad”. His treatment does not include any medical intervention, and I was told to continue managing this through lifestyle (my BMI and waist circumference are in check, low BP, low cholesterol markers, good diet/exercise/sleep habits, mental health in check, etc.)

I don’t have a specific question, however I’m experiencing a lot of turmoil as a result of learning of these results as a relatively young man, and the lack of subsequent treatment/intervention.
I listened to your podcast about lp(a), as well as another (Peter Attia), and came away with the impression that part of the benefit of testing for this early is so that subsequent risk can be mitigated via LDL management which would usually include medication. I understand less regarding the PSA/prostate results, however I am afraid that this may also be potentially undertreated given the circumstances.

In short, I realize you cannot provide medical advice, but it would be helpful and/or reassuring if you could identify any concerns with what has been laid out for me.
I fully admit my concern is being influenced by a bit of a personal crisis, as I am now confronting maladies that are usually expected in later decades, so my apologies if this post seems unnecessary.

Thank you so much in advance!

Hi,

I don’t have additional comments or recommendations regarding the prostate evaluation here.

Regarding the Lp(a); a level of 218 is definitely high. I have attached a graphic illustrating the spectrum of risk based on blood level, account for the number of additional cardiovascular risk factors that a person has (including family history of atherosclerosis, aortic valve stenosis, etc.). We also mentioned this website during the podcast as a tool to help assess risk accounting for this, as well as how risk can be modified by addressing other variables like LDL-c.

As you understand I can’t make specific recommendations in your case here; some might try to treat more aggressively via pharmacologic apoB/LDL-c lowering, whereas others may choose to defer up-front therapy and manage as many of their other risk factors as possible through lifestyle, while monitoring using a tool like a coronary calcium scan.

Hi,

Would you please link the article that’s the source of that graphic? As someone with a high Lp(a) level, I’d like to see some more detail.

Also, how would a CAC score affect the course of treatment? I’d have thought someone with a high Lp(a) level should be pushing lifestyle (diet, exercise, etc.) and LDL-c lowering meds (statins and ezetimibe) in any event. Have any Lp(a) lowering meds finished clinical trials and moved to general use?

Also, how would a CAC score affect the course of treatment? I’d have thought someone with a high Lp(a) level should be pushing lifestyle (diet, exercise, etc.) and LDL-c lowering meds (statins and ezetimibe) in any event. Have any Lp(a) lowering meds finished clinical trials and moved to general use?​

Some patients might prefer CAC monitoring and deferring the use of pharmacotherapy if their score were zero. I am not saying this is a “right” or “wrong” decision.

No meds have yet been approved for general use, although I suspect we are getting close.

If I’m reading correctly, that paper is saying there are technical issues measuring Lp(a), but they are not large enough to change the recommendation that everyone get tested at least once, because Lp(a) is a risk factor in addition to LDC-c.

Random googling suggests Lp(a) meds in 2025, maybe sooner.

Thank you.