I have a friend who I work with as a firefighter that I do programming for and help with training, who recently was diagnosed with prostate cancer for the second time. He wants to continue lifting and working during treatment which is going to include ADT using Lupron Depot and radiation treatment. He had also been on TRT since the initial treatment for his first round of prostate cancer. The information that his oncologist is providing is emphasizing resistance training during ADT which is great but I wanted to see if it might be a good idea to alter his training in any way. Currently he lifts three times a week with full body workouts on all days using squat, bench, deadlifts, and overhead press. Most training is in the “hypertrophy range” (since that is his main goal) with some training blocks in the lower rep ranges, except for bench since he wants to concentrate on strength, so more work in the 1-3 rep ranges with drop down sets and accessory training. Do you think it’s necessary to alter training at all? I was initially thinking more hypertrophy training to conserve muscle but I’m not sure if it’s really necessary. I was also thinking of changing to 4-5 workout split with shorter sessions since he might have less energy or may be unable to train certain days due to the radiation treatment so he could move sessions around or skip certain sessions if needed. We already use RPE based training so I was just going emphasize paying attention to that and not being afraid to reduce intensity or volume as needed. Thanks for any info and if you have any other considerations that would be great.
Sorry to hear about this. It sounds like he has been cleared to resistance train by his oncologist.
I wouldn’t necessarily set negative expectations about what he might experience while on those medications – I have seen a huge range of responses in terms of how people feel on ADT, and there’s no way to predict what he’ll experience.
I would maintain the three day per week schedule. I don’t think there are any specific rep range recommendations I’d make due to the initiation of this treatment – what you are doing appears to be in line with his goals and sounds fine as well. “More hypertrophy training” would primarily involve doing more work sets per week, not necessarily altering rep ranges.
I would not preemptively change to 4-5 shorter sessions on a split schedule unless or until he reports problems with the current lifting schedule. You may find, for example, that he does better with preserved rest days in between training sessions – again, impossible to predict accurately. I would agree with the plan to use RPE or some form of intensity autoregulation; you may find that he needs to autoregulate his per-session volume as well. I agree with the plan to encourage scheduling flexibility to work around treatments like radiation, if needed.
All this is to say that you should alter training based on his individual response, just like we would for anyone else 
Hope that helps and good luck! Let us know how he does.