I am not a Dr and only understand this on a very macroscopic level. But I have recently read up some on David Sinclair, Ph.D., A.O. who is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.
He claims that there are universal regulators of aging, the three pathways, AMPK, mTOR, and Sertuins. Many of these studies are based on mice or even yeast cells. Being a curious nerd is how I came across your website and with as much reading as you gentlemen do I was wondering if you had come across of any of this literature yourselves? Holding out for more human trials? Dr Sinclair takes Resveratol, nicotinamide mononucleotide (NMN) (to boost NAD levels), and Metformin which evidently has been shown for those with and without diabetes to be protected against heart disease, Alzheimer, and frailty.
Just wondering if you had come across any of this and had any thoughts? Thanks.
Yes, we have come across data on those pathways in our education.
The data on resveratrol suggests it may improve insulin resistance in humans, but otherwise has not demonstrated any useful clinical effect via repeated, well-controlled trials. It has no mechanism by which to increase lifespan in humans. Fruit flies are a different story.
NAD+ is a commercial product made by Elysium, which Dr. Sinclair either works for or owns. There is no human data suggesting it is beneficial.
Metformin can be useful in those with insulin resistance and disease processes related to that, such as some forms of cardiovascular disease. That said, it is not useful in those without insulin resistance and is not routinely prescribed for recreational use.
I would not recommend supplementing resveratrol or NAD at this time. I would not recommend obtaining a prescription for metformin unless clinically indicated.
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Thanks,
PS you should go on Joe Rogan’s Podcast! My guess is your demographic has a huge overlap with his, it would be entertaining for me, and its good for your brand…